Current Research Projects

Davis Lab Current Research Projects

Patrick Ronaldson, Ph.D.

CURRICULUM VITAE
 
PATRICK THOMAS RONALDSON, Ph. D.

 Phone:  520-626-2173 · E-Mail: pronald@email.arizona.edu

 
 
 
EMPLOYMENT
 
Research Assistant Professor, 2009-present
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States of America.
 
Postdoctoral Fellow, 2008-2009
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States of America.
Supervisor: Dr. Thomas P. Davis
 
Postdoctoral Fellow, 2007-2008
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
Supervisor:Dr. Reina Bendayan
 
EDUCATION
 
Doctor of Philosophy, 2001-2007
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
Degree conferred November 2007.
Thesis Supervisor: Dr. Reina Bendayan
Thesis Title: Functional Expression of ATP-Binding Cassette (ABC) Transporters in Brain Cellular Compartments and in Glial Cells exposed to HIV-1 Viral Proteins.
 
Bachelor of Science, Honours (with Distinction), Pharmacology, 1995-2000
University of Toronto, Toronto, ON, Canada
Degree conferred June 2000.
 
 
RESEARCH SUPPORT
 
NIH R01 DA011271-11 9/30/09 – 8/30/14 Patrick T. Ronaldson, Co-I. “Blood-to-CNS Drug Uptake in Pain.”
 
Synopsis: This grant studies the uptake into the brain of opioid analgesic drugs and novel opioid peptide drugs. Specifically, this grant will examine drug transport proteins that govern the permeation of opioids into the CNS (i.e., P-glycoprotein, Multidrug Resistance Proteins, Breast Cancer Resistance Protein, Organic Anion Transporting Polypeptides) and regulatory pathways that may alter the functional expression of these transporters during pain/inflammation (i.e., Transforming Growth Factor-beta (TGF-b), IL-6)) and/or pharmacotherapy (i.e., pregnane-X-receptor (PXR), constitutive androstane receptor (CAR))
 
 
PUBLICATIONS
 
Manuscripts
 
Ronaldson P.T., Ashraf T. & Bendayan R. (2010). Regulation of Multidrug Resistance Protein 1 (Mrp1) by tumor necrosis factor alpha (TNF-α) in cultured glial cells: Involvement of Nuclear Factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) signaling pathways. Mol Pharmacol. Accepted January 5, 2010.
 
Ronaldson P.T., DeMarco K.M., Sanchez-Covarrubias L., Solinsky C.M. & Davis T.P. (2009). Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain. J Cereb Blood Flow Metab. 29: 1084-1098.
 
Zastre J.A., Chan G.N, Ronaldson P.T., Ramaswamy M, Couraud P.O., Romero I.A., Weksler B., Bendayan M. & Bendayan R. (2009). Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line. J Neurosci Res. 87: 1023-1036.
 
Ronaldson P.T., Persidsky Y. & Bendayan R. (2008). Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV-1 infection. Glia.56: 1711-1735
 
Ronaldson P.T. & Bendayan R. (2008). HIV-1 envelope glycoprotein gp120 produces oxidative stress and regulates the expression of Multidrug Resistance Protein-1 (Mrp1) in glial cells. J Neurochem. 106: 1298-1313.
 
Bendayan R., Ronaldson P.T., Gingras D. & Bendayan M (2006). In situ localization of P-glycoprotein (ABCB1) in Human and Rat Brain. J Histochem Cytochem. 54: 1159-1167.
 
Ronaldson P.T. & Bendayan R (2006). HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Mol Pharmacol. 70: 1087-1098.
 
Cheung R.Y., Rauth A.M., Ronaldson P.T., Bendayan R. & Wu X.Y. (2005). In vitro toxicity to breast cancer cells of microsphere-delivered mitomycin C and its combination with doxorubicin. Eur. J. Pharm Biopharm. 62: 321-331.
 
Ronaldson P.T., Lee G., Dallas S. & Bendayan R. (2004). Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines. Pharm Res, 21: 811-818.
 
Dallas S., Ronaldson P.T., Bendayan M. & Bendayan R. (2004). Multidrug resistance protein-1-mediated transport of saquinavir in microglia. NeuroReport, 15: 1183-1186.
 
Ronaldson P.T., Bendayan M., Gingras D., Piquette-Miller M. & Bendayan R. (2004). Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J Neurochem. 89: 788-800.
 
Ronaldson P.T. & Bendayan R. (2002). Renal drug transport and drug-drug interactions. J Pharm Prac. 15: 490-503.
 
 
Book Chapters
 
Witt K.A., Ronaldson P.T., Sandoval K.E. & Davis T.P. CNS delivery of peptides across the blood-brain barrier. In: Drug delivery to the central nervous system (K.K. Jain ed). Totowa: Humana Press Inc., 2009.
 
Ronaldson P.T., Babakhanian K. & Bendayan R. Drug transport in the brain. In: Drug Transporters: Molecular Characterization and Role in Drug Disposition (G. You and M. Morris eds). New York: John Wiley & Sons, 2007.
 
 
Submitted Manuscripts
 
Ronaldson P.T., Finch J.D, DeMarco K.M., Quigley C.E. & Davis T.P. (2010). Inflammatory Pain Signals an Increase in Functional Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier. J Neurosci.  Submitted June 28, 2010.
 
Abstracts
 
Ronaldson P.T., Finch J.D., DeMarco K.M., Quigley C.E. & Davis T.P. (2010). Functional expression of organic anion transporting polypeptide 1a4 (Oatp1a4) is increased during peripheral inflammatory pain: Relevance to CNS drug delivery. (Accepted for poster presentation at the Gordon Research Conference: Barriers of the CNS, New London, NH, June 20-25, 2010).
 
Ronaldson P.T., Lochhead JJ, McCaffrey G & Davis T.P. (2009). Hypoxia/Reoxygenation stress alters solute permeability and occludin localization/phosphorylation at the blood-brain barrier. (Accepted for presentation at the Internation Stroke Conference – American Heart Association, San Antonio, TX, February 23-25, 2010).
 
Ronaldson P.T., DeMarco K.M., Sanchez-Covarrubias L., Solinsky C.M. & Davis T.P. (2009). Transforming Growth Factor-β (TGF-β) Signaling is involved in the Regulation of Blood-Brain Barrier (BBB) Functional Integrity during Peripheral Inflammatory Pain. (Accepted for poster presentation at the XXIV Internation Symposium on Cerebral Blood Flow and Metabolism, Chicago, IL, June 29-July 3, 2009).
 
Ronaldson P.T. & Bendayan R. (2008). HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the expression of Multidrug Resistance Protein-1 (Mrp1) in glial cells. (Selected for Poster Presentation at the International Meeting on Clinical Pharmacology and Therapeutics, Quebec City, PQ, July 28-August 2, 2008).
 
Ronaldson P.T., Chan J., Tran C.S. & Bendayan R. (2007). Regulation of P-glycoprotein (P-gp) expression by the mitogen-activated protein kinase (MAPK) pathway in cultured rat astrocytes treated with gp120. Abstract #212. (Selected for Poster Presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 19-20, 2007).
 
Ronaldson P.T., Tran C.S., Rasaiah V.P.A. & Bendayan R. (2007). Increased functional expression of Multidrug Resistance Protein 1 (Mrp1) in cultured glial cells treated with HIV-1 viral envelope protein gp120 and cytokines. Abstract #204. (Selected for Poster Presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 19-20, 2007).
 
Ronaldson P.T., Chan J., Bendayan R. (2007). Involvement of the MAPK Pathway in the Regulation of P-glycoprotein (P-gp) Expression in Cultured Glial Cells Triggered with HIV-1 Envelope Protein Gp120. Abstract #T3456 (Selected for Poster Presentation at the American Association of Pharmaceutical Scientists' Annual Meeting and Exposition, San Diego, CA, November 11-15, 2007).
 
Ronaldson P.T., Tran C.S., Rasaiah V.P., Bendayan R. (2007). Increased functional expression of Multidrug Resistance Protein 1 (Mrp1) in cultured astrocytes treated with HIV-1 viral envelope protein Gp120 or cytokines. Abstract #O003. Can J Infect Dis. 18: 13B. (Selected for Oral Presentation at the 16th Annual Canadian Conference on HIV/AIDS Research, Toronto, ON, April 26-29, 2007).
 
Ronaldson P.T., Chan J., Bendayan R. (2007). Involvement of the mitogen-activated protein kinase (MAPK) pathway in the regulation of P-glycoprotein (P-gp) expression in cultured rat astrocytes treated with gp120. Abstract #P132. Can J Infect Dis. 18: 51B. (Selected for Poster Presentation at the 16th Annual Canadian Conference on HIV/AIDS Research, Toronto, ON, April 26-29, 2007).
 
Zastre J., Chan G., Ronaldson P.T., Ramaswamy M., Bendayan R. (2007). P-glycoprotein mediated transport and induction by the HIV-1 protease inhibitor atazanavir in a human brain microvessel endothelial cell line. Abstract #P140. Can J Infect Dis. 18: 53B. (Selected for Poster Presentation at the 16th Annual Canadian Conference on HIV/AIDS Research, Toronto, ON, April 26-29, 2007).
 
Ronaldson P.T., Chan J. & Bendayan R. Involvement of the Mitogen-Activated Protein Kinase (MAPK) Pathway in the Regulation of P-glycoprotein (P-gp) Expression in Cultured Rat Astrocytes Treated with Gp120. (Selected for poster presentation at the American Association of Pharmaceutical Scientists’ Drug Transporters in ADME Workshop, Bethesda, MD, March 5-7, 2007).
 
Ronaldson P.T., Tran C.S., Rasaiah V.P.A. & Bendayan R. Increased Functional Expression of Multidrug Resistance Protein 1 (Mrp1) in Cultured Astrocytes Treated with HIV-1 Viral Envelope Protein Gp120 orcytokines. (Selected for poster presentation at the American Association of Pharmaceutical Scientists’ Drug Transporters in ADME Workshop, Bethesda, MD, March 5-7, 2007).
 
Ronaldson P.T., Chan J. & Bendayan R. Involvement of the mitogen-activated protein kinase (MAPK) pathway in the regulation of P-glycoprotein (P-gp) expression in cultured rat astrocytes treated with gp120. Abstract #211. (Selected for poster presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 27-28, 2006).
 
Ronaldson P.T., Tran C.S., Rasaiah V.P.A. & Bendayan R. Effect of Gp120 and cytokines on the functional expression of the Multidrug Resistance-Associated Protein-1 (Mrp1), an ATP-binding cassette (ABC) efflux drug transporter, in cultured glial cells. Abstract #210 (Selected for oral and poster presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 27-28, 2006).
 
Ronaldson P.T., Rasaiah V.P.A. & Bendayan R. Increased expression of Multidrug Resistance Protein-1 (Mrp1) in cultured astrocytes treated with HIV-1 viral envelope glycoprotein gp120 or cytokines. Abstract #W-5311. (Selected for poster presentation at the American Association of Pharmaceutical Scientists’ Annual Meeting, San Antonio, TX, October 29-November 2, 2006).
 
Antflick, J.E., Rose E.M., Grant, S., Ronaldson, P.T., Bendayan, R., Baker, G.B., Hampson, D.R. L-serine-O-phosphate: a potential novel transmitter regulating glutamatergic neurotransmission. (Selected for poster presentation at the Society for Neuroscience Annual Meeting: Neuroscience 2006. Atlanta, GA, October 14-18, 2006).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. Functional expression of the ATP-binding cassette (ABC) membrane transporter P-glycoprotein (P-gp; ABCB1) in cultured glial cells treated with gp120. Abstract #TUPE-0076. (Selected for poster presentation at the XVI International AIDS Conference, Toronto, ON, August 13-18, 2006).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. Functional expression of the ATP-binding cassette (ABC) membrane transporter P-glycoprotein (P-gp; ABCB1) in cultured glial cells treated with gp120. (Selected for poster presentation at the Canadian Student Health Research Forum, Winnipeg, MB, June 7-8, 2006).
 
Rose, E.M., Antflick, J.E., Grant, S., Ronaldson, P.T., Bendayan, R., Baker, G.B., Hampson, D.R. (2006) L-serine-O-phosphate: a potential novel transmitter regulating glutamatergic neurotransmission. (Selected for poster presentation at the 49th Annual Meeting and Conference of the Canadian society of Biochemistry, Molecular and Cellular Biology: Membrane Proteins in Health and Disease. Niagara-on-the-Lake, ON, May 31 - June 4, 2006).
 
Rose E.M., Antflick J.E., Grant S., Ronaldson P.T., Bendayan R., Baker G.B. & Hampson D.R. L-serine-O-phosphate: A potential novel gliotransmitter regulating glutamatergic neurotransmission. (Selected for poster presentation at the University of Toronto Program in Neuroscience Poster Day, Toronto, ON, May 12, 2006).
 
Ronaldson P.T., Ramaswamy M. & Bendayan M. Effect of Gp120 and Cytokines on the Functional Expression of P-glycoprotein (P-gp), an ATP Binding Cassette (ABC) Efflux Drug Transporter, in Cultured Glial Cells. Abstract #109. (Selected for oral presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 24-25, 2005).
 
Bendayan R., Ronaldson P.T. & Bendayan M. In situ localization of P-glycoprotein (ABCB1) in human and rat brain: relevance to the treatment of HIV-1 infection in the brain. Abstract #247. (Selected for poster presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 24-25, 2005).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. In Vitro Treatment Of Cultured Glial Cells With Gp120, An HIV-1 Viral Envelope Protein, Modulates the Functional Expression of the ATP-Binding Cassette (ABC) Transporter P-Glycoprotein (P-gp). Abstract #R6274. (Selected for oral and poster presentation at the American Association of Pharmaceutical Scientists’ Annual Meeting, Nashville, TN, November 6-10, 2005).
 
Bendayan R., Ronaldson P.T. & Bendayan M. In situ localization of P-glycoprotein (ABCB1)in human and rat brain. Abstract #R6275. (Selected for poster presentation at the American Association of Pharmaceutical Scientists’ Annual Meeting, Nashville, TN, November 6-10, 2005).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. Effect of HIV-1 viral envelope glycoprotein gp120 on the Functional Expression of P-glycoprotein (P-gp) in Cultured Glial Cells. (Selected for poster presentation at the Canadian Society for Pharmaceutical Sciences Symposium, Toronto, ON, May 30-June 2, 2005).
 
Guindy M., Ronaldson P.T., Ramaswamy M. & Bendayan R. Molecular expression of chemokine receptors in brain microvessel and glial cell culture systems (Selected for poster presentation at the Canadian Society for Pharmaceutical Sciences Symposium, Toronto, ON, May 30-June 2, 2005).
 
Bendayan R., Ronaldson P.T. & Ramaswamy M. Effect of gp120 on the functional expression of the ATP-Binding Cassette (ABC) membrane transporter P-glycoprotein (P-gp; ABCB1) in cultured glial cells. (Selected for poster presentation at the 6th International Workshop on the Clinical Pharmacology of HIV Therapy, Quebec City, PQ, April 28-30, 2005).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. Effect of Gp120, an HIV-1 Viral Envelope Protein, on the Functional Expression of P-glycoprotein (P-gp) and Multidrug Resistance Protein 1 (Mrp1) in Cultured Glial Cells. (Selected for poster presentation at the American Association of Pharmaceutical Scientists Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Parsippany, NJ, March 7-9, 2005).
 
Ronaldson P.T., Ramaswamy, M. & Bendayan R. Modulation of Drug Efflux Transporters in Glial Cells Treated with the HIV-1 Viral Coat Protein gp120. (Selected for poster presentation at the Ontario HIV Treatment Network Research Conference, Toronto, ON, November 25-26, 2004).
 
Ronaldson P.T., Ramaswamy M. & Bendayan R. Effect of Lipopolysaccharide (LPS) Treatment on the Expression of P-glycoprotein (P-gp) and Multidrug Resistance Protein 1 (Mrp1) in Cultured Glial Cells. (Selected for poster presentation at the American Association of Pharmaceutical Scientists’ Annual Meeting, Baltimore, MD, November 7-11, 2004).
 
Bendayan R., Ronaldson P.T., Lee G., Gingras D. & Bendayan M. Localization of P-glycoprotein (ABCB1, P-gp) in brain cellular compartments. (Selected for a poster presentation at the International Congress of Histochemistry and Cytochemistry, San Diego, CA, July 24-28, 2004).
 
Ronaldson P.T., Bendayan M., Gingras D. & Bendayan R. Molecular expression and physical association of P-glycoprotein (P-gp) and caveolin-1 in rat astrocyte cultures. (Selected for a poster presentation at the Gordon Research Conference on Barriers of the Central Nervous System, Tilton, NH, June 27-July 2, 2004).
 
Dallas S., Ronaldson P.T., Zhu X., Schlichter L. & Bendayan R. MRP4- and MRP5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) by microglia. (Presented as a poster at the American Society of Clinical Pharmacology and Therapeutics Annual Meeting, Miami Beach, FL, March 24-27, 2004).
 
Ronaldson P.T., Bendayan M., Gingras D., Bendayan R. Molecular Expression and Subcellular Localization of P-glycoprotein (P-gp) in Rat Astrocyte Cultures: Relevance to the Treatment of HIV-1 Infection in the CNS. (Presented as a poster at the Ontario HIV Treatment Network Research Day, Toronto, ON, November 3-4, 2003).
 
Ronaldson P.T., Gingras D., Piquette-Miller M., Bendayan M. & Bendayan R. Localization and functional expression of P-glycoprotein (P-gp) in rat astrocyte cultures: Relevance to the treatment of HIV-1 infection in the central nervous system (CNS). (Presented as a poster at the Cerebrovascular Biology Annual Meeting, Amarillo, TX, June 15-19, 2003).
 
Ronaldson P.T., Gingras D, Piquette-Miller M, Bendayan M & Bendayan R. Localization and functional expression of P-glycoprotein in rat astrocyte cultures. Abstract #A23. (Presented as a poster at the Association of Faculties of Pharmacy of Canada Annual Meeting, Montreal, PQ, May 29-June 1, 2003).
 
Ronaldson P.T., Bendayan M, Piquette-Miller M & Bendayan R. Functional expression of P-glycoprotein in rat astrocyte cultures: relevance to the treatment of HIV-1 infection in the brain. (Presented as a poster at the American Association of Pharmaceutical Scientists’ Workshop on Drug Transport, Peachtree City, GA, February 9-12, 2003).
 
Lee G, Ronaldson P.T. & Bendayan R. P-glycoprotein mediated transport of saquinavir and indinavir at the blood-brain barrier and in brain parenchyma. (Presented as a poster at the American Association of Pharmaceutical Scientists’ Workshop on Drug Transport, Peachtree City, GA, February 9-12, 2003).
 
Ronaldson P.T., Piquette-Miller M & Bendayan R. Functional expression of P-glycoprotein (P-gp) in rat astrocyte cultures: relevance to the treatment of HIV-1 infection in the brain. (Presented as a poster at the Ontario HIV Treatment Network Research Day, Toronto, ON, November 28-29, 2002).
 
Ronaldson P.T., Piquette-Miller M & Bendayan R. Functional expression of P-glycoprotein (P-gp) in rat astrocyte cultures: relevance to the treatment of HIV-1 infection in the brain. (Presented as a poster at the American Association of Pharmaceutical Sciences Annual Meeting, Toronto, ON, November 10-14, 2002).
 
Lee G, Ronaldson P.T. & Bendayan R. P-glycoprotein mediated transport of saquinavir at the blood-brain barrier and brain parenchyma. (Presented as a poster at the American Association of Pharmaceutical Sciences Annual Meeting, Toronto, ON, November 10-14, 2002).
 
Lee G, Ronaldson P.T. & Bendayan R. P-glycoprotein (P-gp) mediated transport of saquinavir (SAQ) across the blood-brain barrier (BBB) and microglia (2002). Can J Infect Dis. 13; 141P. (Presented as a poster at the 11th Annual Canadian Conference on HIV/AIDS Research, Winnipeg, MB, April 25-28, 2002).
 
Ronaldson P.T., Dallas S, Piquette-Miller M & Bendayan R. Functional expression of P-glycoprotein (P-gp) in primary rat astrocyte cultures: relevance to the treatment of HIV infection in the brain. Can J Infect Dis. 13; 151P. (Presented as a poster at the 11th Annual Canadian Conference on HIV/AIDS Research, Winnipeg, MB, April 25-28, 2002).
 
Ronaldson P.T., Dallas S, Pallapothu M & Bendayan R (2002). Functional expression of P-glycoprotein (P- gp) in primary rat astrocyte cultures and an immortalized rat astrocyte cell line (DI-TNC). Clin Pharmacol Ther. 71; P15. (Presented as a poster and an oral presentation at the American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Atlanta, GA, March 24-27, 2002).
 
Ronaldson P.T., Dallas S, Pallapothu M & Bendayan R (2002). Transport of saquinavir (SAQ) by P-glycoprotein and the multidrug-resistance protein (MRP) in an immortalized endothelial cell line (RBE4). Clin Pharmacol Ther. 71; P51. (Presented as a poster and an oral presentation at the American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Atlanta, GA, March 24-27, 2002).
 
 
 
SCHOLARSHIPS
 
Ontario HIV Treatment Network (OHTN) Studentship Award (September 2005-August 2007).
 
Ontario HIV Treatment Network (OHTN) Studentship Award (September 2003-August 2005).
 
University of Toronto Open Scholarship (September 2002).
 
Merck-Frosst Canada Studentship Award (September 2001-August 2003).
 
 
 
ACADEMIC AWARDS
 
American Association of Pharmaceutical Scientists Postdoctoral Researcher Travel Award (Awarded for outstanding abstract by a postdoctoral fellow, November 2007).
 
AFPC-GlaxoSmithKline Graduate Student Research Award (Awarded for best scientific paper written by a doctoral student at a Canadian school of pharmacy, June 2007).
 
Gordon Cressy Student Leadership Award (Awarded by the University of Toronto Alumni Association and the Division of University Advancement. March 2007).
 
Canadian Student Health Research Forum Poster Award (Awarded by the Canadian Institutes of Health Research, June 2006).
 
Association of Faculties of Pharmacy of Canada Graduate Student Poster Award (May 2003).
 
American Association of Pharmaceutical Scientists Certificate of Excellence for Top Research Abstract (February 2003).
 
Piafsky Memorial Trainee Presentation Award (Awarded by the Canadian Society for Clinical Pharmacology, March 2002).
 
 
 
CONFERENCES ATTENDED
 
Gordon Research Conference: Barriers of the CNS, New London, NH, June 20-25, 2010
Ø       Oral and Poster Presentation
 
Ontario HIV Treatment Network Research Conference. Toronto, ON. November 19-20, 2007.
Ø       Poster Presentation
 
American Association of Pharmaceutical Scientists’ Annual Meeting, San Diego, CA, USA. November 9-15, 2007.
Ø       Poster Presentation/Award Winner
 
7th Cerebral Vascular Biology International Conference. Ottawa, ON. June 24-28, 2007.
Ø       Oral Presentation
 
Association of Faculties of Pharmacy of Canada Annual Meeting. Montreal PQ. May 30-June 2, 2007.
Ø       Oral Presentation/Award Winner.
 
16th Annual Canadian Conference on HIV/AIDS Research, Toronto, ON, April 26-29, 2007
Ø       Oral and Poster Presentation
 
Ontario HIV Treatment Network Research Conference. Toronto, ON. November 27-28, 2006.
Ø       Oral and Poster Presentation
 
American Association of Pharmaceutical Scientists’ Annual Meeting. San Antonio, TX, USA. October 29-November 2, 2006.
Ø       Poster Presentation
 
XVI International AIDS Conference. Toronto, ON, August 13-18, 2006
Ø       Poster Presentation
 
Canadian Student Health Research Forum. Winnipeg, MB, June 7-8, 2006.
Ø       Poster Presentation
 
Ontario HIV Treatment Network Research Conference. Toronto, ON, November 24-25, 2005
Ø       Oral and Poster Presentation
 
American Association of Pharmaceutical Scientists’ Annual Meeting. Nashville, TN, USA. November 6-10, 2005.
Ø       Oral and Poster Presentation
 
Canadian Society for Pharmaceutical Sciences Symposium, Toronto, ON, May 30-June 2, 2005.
Ø       Poster Presentation
 
Ontario HIV Treatment Network Research Conference, Toronto, ON, November 25-26, 2004.
Ø       Poster Presentation
 
American Association of Pharmaceutical Scientists’ Annual Meeting. Baltimore, MD, USA. November 7-11, 2004.
Ø       Poster Presentation
 
Ontario HIV Treatment Network Research Day. Toronto, ON. November 3-4, 2003.
Ø       Poster Presentation
 
Association of Faculties of Pharmacy of Canada Annual Meeting. Montreal PQ. May 29-June 1, 2003.
Ø       Poster Presentation/Award Winner for best Abstract.
 
American Association of Pharmaceutical Scientists Workshop on Drug Transport. Peachtree City, GA, USA. February 9-12, 2003.
Ø       Poster Presentation/Award Winner for best Poster
 
Ontario HIV Treatment Network Research Day. Toronto, ON. November 28-29, 2002.
Ø       Poster Presentation
 
American Association of Pharmaceutical Scientists Annual Meeting. Toronto, ON. November 10-14, 2002.
Ø       Poster Presentation
 
11th Annual Canadian Conference on HIV/AIDS Research. Winnipeg, MB. April 25-28, 2002.
Ø       Poster Presentation
 
American Society for Clinical Pharmacology and Therapeutics Annual Meeting. Atlanta, GA, USA. March 24-27, 2002.
Ø       Poster and Oral Presentation/Award Winner for Best Oral Presentation/Award Winner for Best Poster
 
 
 
OTHER PRESENTATIONS
 
Ronaldson P.T. Involvement of transforming growth factor-β (TGF-β) signaling on the regulation of ight junction proteins at the blood brain barrier during inflammatory pain. (Invited Oral Presentation at the Gordon Research Conference “Barriers of the CNS” to be held at Colby-Sawyer College, New London, NH, June 20-25, 2010).
 
Ronaldson P.T. Altered Blood-Brain Barrier Integrity during Inflammatory Pain: A Role for Transforming Growth Factor-β (TGF-β) Signaling. (Invited Oral Presentation at the Department of Medical Pharmacology Research Seminar Series, University of Arizona, October 7, 2009).
 
Ronaldson P.T. Effect of Gp120 and Cytokines on the Functional Expression of ABC Drug Efflux Transporters in Cultured Astrocytes. (Invited Oral Presentation at the Toronto HIV Research Group Meeting, University of Toronto, February 6, 2007).
 
Ronaldson P.T. Effect of HIV-1 Viral Envelope Glycoprotein Gp120 on the Functional Expression of P-glycoprotein (P-gp) in Primary Cultures of Rat Astrocytes. (Oral Presentation at the Receptors, Channels, and Transporters Group Meeting, Leslie Dan Faculty of Pharmacy, University of Toronto, November 19, 2005).
 
Ronaldson P.T.  Modulation of Drug Efflux Transporters in Glial Cells Treated with the HIV-1 Viral Coat Protein gp120. (Poster Podium Presentation for World AIDS Day, Leslie Dan Faculty of Pharmacy, University of Toronto, December 1, 2004).
 
Ronaldson P.T. Modulation of P-glycoprotein and Multidrug Resistance Protein 1 in an in vitro model of HIV-1 Encephalitis (Oral Presentation at the Oxidative Stress Consortium Graduate Student Symposium, University of Toronto, Toronto, ON, August 25, 2004).
 
Ronaldson P.T. Anti-HIV Drugs and the Brain. (Oral Presentation at the Canadian AIDS Treatment Information Exchange (CATIE), Toronto, ON, July 26, 2004).
 
GRADUATE COURSES
 
Cellular and Molecular Neuroscience (JNR1444Y), September 2004-April 2005 (Grade: A)
 
Chemical Basis of Drug Metabolism (PHM1110H), January 2004-April 2004 (Grade: A+)
 
Graduate Course in Clinical Pharmacology (PCL1004Y), September 2001-April 2002 (Grade: A+).
 
Drug Transport across Biological Membranes (JFK1122H), January 2001-April 2001 (Grade: A-).
 
 
TEACHING EXPERIENCE
 
Facilitator, Case Based Instruction Block – Cardiovascular, Pulmonary, and Renal (CBI I)
                      College of Medicine, University of Arizona
                      February 2010-May 2010
 
Lecturer, Pharmacological Basis of Therapeutics (PHCL501A)
                      Department of Medical Pharmacology, University of Arizona
                      January 2010-April 2010
 
Course Coordinator and Lecturer, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto        
                      September 2007-April 2008 
 
Course Coordinator and Lecturer, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto        
                      September 2006-April 2007
 
Course Coordinator and Lecturer, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto
                      September 2005-April 2006
 
Teaching Assistant, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto        
                      September 2004-April 2005 (150 hours)
 
Teaching Assistant, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto
                      September 2003-April 2004 (100 hours)
 
Teaching Assistant, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto        
                      September 2002-April 2003 (80 hours)
 
Teaching Assistant, Clinical Biochemistry, Pathophysiology, and Pathology (PHM330Y)
                      Leslie Dan Faculty of Pharmacy, University of Toronto        
                      September 2001-April 2002 (80 hours)
 
 
 
 
OTHER POSITIONS HELD
 
Member, Drug Transport Focus Group, American Association of Pharmaceutical Scientists.
                        January 2010-current
 
Postdoctoral Fellow Member, Drug Transport Focus Group, American Association of Pharmaceutical Scientists.
                        September 2007-December 2009.
 
Graduate Student Member, Drug Transport Focus Group, American Association of Pharmaceutical Scientists.
                        September 2006-August 2007.
 
Graduate Student Member, Teaching Assistants’ Committee, Leslie Dan Faculty of Pharmacy, University of Toronto.
                        September 2006-August 2007.
 
President, Pharmaceutical Sciences Graduate Students’ Association, Leslie Dan Faculty of Pharmacy, University of Toronto.
                        September 2005-August 2006.
 
At-Large Member, American Association of Pharmaceutical Scientists’ Student Chapter at the University of Toronto.
                        September 2005-August 2006.
 
Student Member, Leslie Dan Faculty of Pharmacy Academic Appeals Committee, University of Toronto.
                        September 2005-August 2006.
 
President, Pharmaceutical Sciences Graduate Students’ Association, Leslie Dan Faculty of Pharmacy, University of Toronto.
                        September 2004-August 2005.
 
At-Large Member, American Association of Pharmaceutical Scientists’ Student Chapter at the University of Toronto.
                        September 2004-August 2005
 
Student Member, Leslie Dan Faculty of Pharmacy Academic Faculty Cross-Appointment Committee, University of Toronto.
                        September 2004-August 2005.
 
President, Pharmaceutical Sciences Graduate Students’ Association, Leslie Dan Faculty of Pharmacy, University of Toronto.
                        September 2003-August 2004.
 
Secretary/Treasurer, Pharmaceutical Sciences Graduate Students’ Association, Leslie Dan Faculty of Pharmacy, University of Toronto.
                        September 2002-August 2003