Current Research Projects

Davis Lab Current Research Projects

Publications

Lyden, P., H. Levy, S. Weymer, K. Pryor, W. G. Kramer, J. H. Griffin, T. P. Davis, and B.V. Zlokovic. Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult volunteers. Current Pharmaceutical Design. 19. 2013. http://www.ncbi.nlm.nih.gov/pubmed/24372304

Ronaldson, P.T., and T.P. Davis. Gabapentin and diclofenac reduce opioid consumption in patients undergoing tonsillectomy : A result of altered CNS delivery ? Arch Trauma Res. 2, 2. 97-98. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876552/

Sanchez-Covarrubias, L., Ronaldson P.T. T. W. Vanderah, and T.P. Davis. P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.  PLOS One. In Press. 2013. http://www.ncbi.nlm.nih.gov/pubmed/24520393

Mosnier, L.O., J.A. Fernandez, T.P. Davis, B.V. Zlokovic and J.H. Griffin. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of tPA and of tPA on the variant’s anticoagulant activity . J Thrombosis Haemostasis. 11, 11. 2059-2062. 2013. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850769/

Guo, H., R.D. Bell, S. Wang, A. Sagare, N. Chow, T.P. Davis, J.H. Griffin, S.A. Goldman and B.V. Zlokovic. An activated protein C analog stimulates neuronal production by human neuronal progenitor cells via PAR1-PAR3-S1P-Akt pathway. J. Neuroscience. 33,14. 6181-6190. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23554499

Sanchez-Covarubias, L., T.P. Davis and P.T. Ronaldson. Drug transporters at CNS Barrier Sites:  Obstacle or Opportunity for drug delivery? Current Pharmaceutical Design. June, 19. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23789948

Slosky, L.M., B.J. Thompson, L. Sanchez-Covarubias, Y. Zhang, M. Laracuente, T. W. Vanderah,  P.T. Ronaldson and T. P. Davis. Acetaminophen modulates P- glycoprotein functional expression  at the blood-brain barrier by a constitutive androstane receptor–dependent mechanism. Molecular Pharmacology. 84, 5. 774-786. 2013. http://www.ncbi.nlm.nih.gov/pubmed/24019224

Ronaldson, P.T. and T.P. Davis. Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacological Reviews. 65,1. 291-314. 2013. http://www.ncbi.nlm.nih.gov/pubmed/23343976

Mc Caffrey, G., and T.P. Davis.  Physiology and pathophysiology of the blood brain barrier: p-glycoprotein and occludin trafficking as therapeutic targets to optimize CNS drug delivery. Journal of Investigative Medicine. 60:8. 1131-1140.2012. http://www.ncbi.nlm.nih.gov/pubmed/23138008

Wang, Y., Z. Zhang, N. Chow, T.P. Davis, J.H. Griffin, M. Chopp, and B.V. Zlokovic. An activated protein C analog with reduced anticoagulant activity enhances tPA treatment for ischemic stroke in rodents. Stroke.43:2444-2449.2012. http://www.ncbi.nlm.nih.gov/pubmed/22811462

Ronaldson, P.T. and T. P. Davis. Blood –Brain Barrier Integrity and Glial Support: Mechanisms that can be targeted for novel therapeutic approaches in stroke. Current Pharmaceutical Design. 18,25. 3624-3644. 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918413/

Williams, P.D., Zlokovic, B.V., Griffin, J.H., Pryor, K.E., and T. P. Davis. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified Activated Protein C for Ischemic Stroke. Current Pharmaceutical Design.18:4215-4222. 2012. http://www.ncbi.nlm.nih.gov/pubmed/22632606

Mc Caffrey, G., Staatz, W., Ronaldson, P.T., Finch, J.D., DeMarco, K.M., Laracuente, M., and T.P. Davis. P-glycoprotein trafficking at the blood brain barrier altered by peripheral inflammatory hyperalgesia. J. Neurochemistry. 1471-4159.2012.07831.2012. http://www.ncbi.nlm.nih.gov/pubmed/22716933

Ronaldson, P.T. and T.P. Davis. Targeting Blood Brain Barrier Changes during Inflammatory Pain: An Opportunity for Optimizing CNS Drug Delivery. Therapeutic Delivery. 2:1015-1041. 2011 http://www.ncbi.nlm.nih.gov/pubmed/22468221

Lochhead, J.J., G. McCaffrey, C. Quigley, J. Finch, K. DeMarco, T.P. Davis and P. T. Ronaldson. Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood brain barrier during inflammatory pain.  Amer. J. of Physiology: Heart and Circ Physiology.  302:H582-H593. 2011. http://www.ncbi.nlm.nih.gov/pubmed/22081706

Ronaldson, P.T., J. D. Finch, K.M. DeMarco, C.M. Solinsky, C. E. Quigley and T.P. Davis. Inflammatory Pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood brain barrier. J. Pharmacology Experimental Therapeutics.  336,3. 827-839.2011. http://www.ncbi.nlm.nih.gov/pubmed/21131267

Lochhead, J. J., G. McCaffrey, C. E. Quigley, J. Finch, K. DeMarco and T.P. Davis. Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J. Cerebral Blood Flow and Metabolism. 30,9.1625-1636. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20234382

Willis, C.L., D. S. Meske, and T.P. Davis. Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and post-hypoxic reoxygenation .  J. Cerebral Blood Flow and Metabolism. 30,11. 1847-1859.2010. http://www.ncbi.nlm.nih.gov/pubmed/20700133

Ronaldson, P.T., K.M. DeMarco, L. Sanchez-Covarubias, C.M. Solinsky and T.P. Davis.   Transforming growth factor Beta signaling alters permeability and tight junction protein expression at the blood brain barrier during inflammatory pain.J. Cerebral Blood Flow and Metabolism 29,6. 1084-1098.2009. http://www.ncbi.nlm.nih.gov/pubmed/19319146

Wang, Y., M. Thiyagarajan, N. Chow, I. Singh, H. Guo, T.P. Davis and B. Zlokovic. Differential     Neuroprotection and Risk for Bleeding from Activated Protein C with varying degree of Anticoagulant Activity. Stroke 40, 5. 1864-1869. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19057019

McCaffrey, G.W., C Willis, W. Staatz, N. Nametz, C. Quigley, S. Hom, J. Lochhead and T.P. Davis. Occludin oligomeric assemblies at tight junctions of the blood brain barrier dynamically respond to hypoxia and reoxygenation stress. J. Neurochemistry 110,1:58-71.2009. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313603/

McCaffrey, G.W., M.J. Seelbach, W.D. Staatz, N Nametz, C. Quigley, C.R. Campos, T.A. Brooks and T.P. Davis. Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia. J. Neurochemistry.  106(6):2395-2409. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18647175

Brooks, T.A., N. Nametz, R. Charles and T.P. Davis. Diclofenac attenuates the regional effect of
Lambda carrageenan on BBB function and cytoarchitecture. J.Pharmacol Exp.Ther.  2008.
http://www.ncbi.nlm.nih.gov/pubmed/18305016?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Neuwelt, E., N. Joan Abbott, L.Abrey, W. A. Banks, B. Blakley, T.P. Davis, B. Engelhardt, P. Grammas, M. Nedergard, J. Nutt, W. Pardridge, G. Rosenberg, Q. Smith and L. Drewes.
Strategies to advance translational research into brain barriers.  Lancet Neurology Volume 7, January 2008. http://www.ncbi.nlm.nih.gov/pubmed/18093565

Campos, C.R., S, Hom,  R.D. Egleton and T.P. Davis. Nociceptive inhibition prevents inflammatory pain induced changes in the blood brain barrier. Brain Research (in press).2008. http://www.ncbi.nlm.nih.gov/pubmed/18554577

McCaffrey, G., W. Staatz, R. Egleton, M. Seelbach, C. Campos and T.P. Davis. Tight Junctions contain Oligomeric protein assembly critical for maintaining Blood Brain Barrier integrity in vivo.  J. Neurochemistry 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17931362?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Seelbach, M.J., J.D. Huber, T. Brooks, R.D. Egleton, K.A. Witt and T.P. Davis. Effect of lambda carrageenan-induced inflammatory pain on brain uptake of morphine and the potential role of P-glycoprotein. J. Neurochemistry . 102,5.1677-1689. 2007. 

Witt, K.A., K.S. Mark , K. Sandoval and T.P. Davis. Reoxygenation stress on Blood Brain Barrier Paracellular Permeability and Edema in the Rat. Microvascular Research doi:10.1016/J.MVR.2007.06.004. 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17651765?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hom, S., M.A. Fleegal, R.D. Egleton, C.R. Campos, B. Hawkins  and T.P. Davis. Comparative changes is the blood brain barrier and cerebral infarction of SHR and WKY rats. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 292 (5).1881-1892. 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17234953?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brooks, T.A.,  C.R. Campos, R.D. Egleton, M. Seelbach, N. Nametz and T.P. Davis. Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain. Brain Research 1120(1).172-182. 2006.
http://www.ncbi.nlm.nih.gov/pubmed/17007822?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A. and T.P. Davis. CNS Drug Delivery: Opioid Peptides and the Blood Brain Barrier. The AAPS Journal 7 (4) 9. 2006.
http://www.ncbi.nlm.nih.gov/pubmed/16584136?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J.D., C.R. Campos, K.S. Mark and T.P. Davis. Alterations in blood-brain barrier ICAM-1 expression and microglial activation following lambda carrageenan induced inflammatory pain. American Journal of Physiology (Heart and Circulatory) 290(2):H732-740. 2006. http://www.ncbi.nlm.nih.gov/pubmed/16199477?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Fleegal, M.A., S. Hom, L.K. Borg and T.P. Davis. Hypoxia and post-hypoxic reoxygenation modulate PKC activity and protein expression in endothelial cells of the blood-brain barrier. American J. Physiology (Heart and Circulatory) 289(5):H2012-2019.2005. http://www.ncbi.nlm.nih.gov/pubmed/15994856

Hawkins, B. T. and T.P. Davis. The blood-brain barrier/neurovascular unit in health and disease. Pharmacological Reviews 57(2):173-185, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15914466?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hawkins, B.T., R.D. Egleton and T.P. Davis. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. American J. Physiology (Heart and Circulatory) 289(1): H212-H219. 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15708958?ordinalpos=21&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brooks, T.A., B.T. Hawkins, J.D. Huber, R.D. Egleton and T.P. Davis. Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations. American J. Physiology (Heart and Circulatory) 289(2):H738-H743. 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15792985?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D. and T.P. Davis. Development of Neuropeptide Drugs that Cross the Blood- Brain Barrier. NeuroRx.   Jan; 2(1), 44-53. 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15717056?ordinalpos=20&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brown, R.C. and T.P. Davis. Hypoxia/Aglycemia alters expression of occludin and actin in brain endothelial cells. Biochemical and Biophysical Research Communications 327(4):1114-1123, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15652512?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., K.S. Mark, J.D. Huber and T.P. Davis. Hypoxia Inducible Factor and Nuclear Factor Kappa-B Activation in Blood Brain Barrier Endothelium under Hypoxic/Reoxygenation Stress. J. Neurochemistry 92(1):203-214, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15606909?ordinalpos=25&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Doolittle,N., L.E. Abrey, W. Bleyer, S.Brem, T.P. Davis, P. Dore-Duffy, L. Drewes, W. Hall, J. Hoffman, A. Korfel, R. Martuza, L. Muldoon, D. Peereboom, D. Peterson, S. Rabkin, Q. Smith, G. Stevens and E. A. Neuwelt. New Frontiers in Translational Research in Neuro-Oncology and the Blood-Brain Barrier: Report of the Tenth Annual Blood- Brain Barrier Disruption Consortium Meeting. Clinical Cancer Research 11:421-428, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15701824?ordinalpos=22&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hau, V.S., J.D. Huber, C.R. Campos, R.T. Davis and T.P. Davis. Effect of lambda carrageenan induced inflammatory pain on brain uptake of codeine and antinociception. Brain Research 1018(2):257-264, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15276886?ordinalpos=31&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Landen, J.W., V. Hau, M. Wang, T.P. Davis, B. Celiax, B.H. Wainer, E.G. Glass, H.C. Joshi and D.R. Archer. Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth. Clinical Cancer Research 10(15):5187-5201, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15297423?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hawkins, B.T., T.J. Abbruscato, R.D. Egleton, R.C. Brown, J.D. Huber, C.R. Campos, and T.P. Davis.  Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.  Brain Research 1027(1-2):48-58, 2004.http://www.ncbi.nlm.nih.gov/pubmed/15494156?ordinalpos=28&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brown, R.C., K.S. Mark and T.P. Davis.  Protection against hypoxia-induced blood brain barrier disruption: Changes in intracellular calcium. American Journal of Physiology- Cell Physiology 286(5):C1045-1052, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15075203?ordinalpos=34&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Mark, K.S., A. Burroughs and T.P. Davis.  Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature.  American J. Physiology-Heart and Circulatory Physiology 286(1):H174-180, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/12958038?ordinalpos=37&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brown, R.C., R.D. Egleton and T.P. Davis.  Mannitol opening of the blood brain barrier: regional variation of sucrose, 86-Rb, or albumin. Brain Research 1014(1-2):221-227, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15213006?ordinalpos=33&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Wolka, A., J.D. Huber and T.P. Davis.  Pain and the Blood Brain Barrier: obstacles to drug delivery.  Advanced Drug Delivery Reviews 55(8):987-1006, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12935941?ordinalpos=38&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brown, R.C., K.S. Mark, R.D. Egleton, J.D. Huber, A.R. Burroughs and T.P. Davis.  Protection against hypoxia-induced increase in blood-brain barrier permeability: Role of Tight Junction Proteins and NF kappa B. Journal of Cell Science 116(4):693-700, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12538770?ordinalpos=44&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., K.S. Mark, S. Hom and T.P. Davis.  Effect of Hypoxia/Reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.  American J. Physiology-Heart and Circulatory Physiology 285(6):H2820-2831, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12907427?ordinalpos=40&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Ritchie, J.C., T.P. Davis, and C.B. Nemeroff.   Action of three ectopeptidases on corticotropin-releasing factor: Metabolism and functional aspects. Neuropsychopharmacology 28(1):22-33, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12496937?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D., C.R. Campos, J.D. Huber, R.C. Brown and T.P. Davis.  Differential effects of diabetes on rat choroid plexus ion transporter expression.  Diabetes 52:1496-1501, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12765962?ordinalpos=43&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J.D., R.D. Egleton and T.P. Davis.  Conjugation of low molecular weight polyethylene glycol to biphalin enhances antinociceptive profile.  J. Pharm. Sci. 92:1377-1385, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12820142?ordinalpos=41&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J., V.S. Hau, K.S. Mark, R.C. Brown, C.R. Campos and T.P. Davis. Viability of  microvascular endothelial cells to direct exposure of formalin, lambda-carrageenan and complete Freund’s adjuvant.  European J. Pharmacology 450(3):297-304, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12208323?ordinalpos=51&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A. and T.P. Davis. Pluronic P85 block copolymer enhances opioid peptide analgesia.  J. Pharmacol. Exp. Ther. 303(2):760-767, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12388663?ordinalpos=48&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hawkins, B.T., R.C. Brown and T.P. Davis.  Smoking and ischemic stroke: A role for nicotine?  Trends in Pharmacological Sciences 23(2):78-82, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/11830264?ordinalpos=54&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J.D., V.S. Hau, C.R. Campos, R.D. Egleton and T.P. Davis.  Blood-brain barrier tight junctions are altered during a 72-h exposure to lambda-carrageenan-induced inflammatory pain.  American J. Physiology-Heart and Circulatory Physiology 283(4):H1531-H1537, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12234806?ordinalpos=49&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hau, V., J. Huber, R. Egleton and T.P. Davis.  The effect of guanidino modification and proline substitution on the in vitro stability and BBB permeability of endomorphin II.  J. Pharm. Sci. 91(10):2140-2149. 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12226841?ordinalpos=50&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Brown, R.C. and T.P. Davis.  Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke.  Stroke 33(6):1706-1711, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12053015?ordinalpos=52&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Mark, K.S. and T.P. Davis.  Cerebral microvascular changes in permeability and tight junctions induced by hypoxia- reoxygenation.  American J. Physiology-Heart and Circulatory Physiology 282(4):H1485-H1494, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/11893586?ordinalpos=53&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J., K.S. Mark, B. Hawkins and T.P. Davis. Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of Z0-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. J. Pharm. Sci. 91(12):2525-2538, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12434396?ordinalpos=46&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J.D., R.D. Egleton and T.P. Davis.  Molecular physiology and pathophysiology of blood-brain barrier tight junction.  Trends in the Neurosciences 24(12):719-725, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11718877?ordinalpos=56&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., J.D. Huber, R.D. Egleton, M.J. Roberts, M.D. Bentley, L. Guo, H. Wei, H.I. Yamamura and T.P. Davis.  Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to Met-enkephalin analogue DPDPE.  J. Pharmacol. Exp. Therap. 298(2):848-856, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11454951?ordinalpos=59&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., T.J. Gillespie, R.D. Egleton, J.D. Huber and T.P. Davis.  Peptide drug modification to enhance bioavailability and blood brain barrier permeability.  Peptides 22:2329-2243, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11786210?ordinalpos=55&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hom, S, R.D. Egleton, T.J. Abbruscato and T.P. Davis.  Effect of reduced flow on blood-brain barrier transport systems.  Brain Research 890(1):38-48, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11164767?ordinalpos=63&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D., S.A. Mitchell, J. Huber, M.M. Palian, R. Polt, and T.P. Davis.  Improved Blood-Brain Barrier Penetration and Enhanced Analgesia of an Opioid Peptide by Glycosylation.  J. Pharmacol. Exp. Therap. 299(3):967-972, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11714884?ordinalpos=57&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Moody, T.W., J. Chiles, M. Casibang, E.L. Moody, D. Chan and T.P. Davis. SR48692 is a neurotensin receptor agonist which inhibits the growth of small cell lung cancer cells.  Peptides 22:109-115, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11179604?ordinalpos=61&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Huber, J.D., K.A. Witt, S. Hom, R.D. Egleton, K.S. Mark, and T.P. Davis. Inflammatory pain alters blood brain barrier permeability and tight junctional protein expression.  American. J. Physiology-Heart and Circulatory Physiology. 280:H1241-H1248, 2001.
http://www.ncbi.nlm.nih.gov/pubmed/11179069?ordinalpos=62&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., R.D. Egleton, J.D. Huber and T.P. Davis. Insulin enhancement of opioid peptide transport across the blood-brain barrier and assessment of analgesic effect.  J. Pharmacol. Exp. Therap. 295(3):972-978, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/11082431?ordinalpos=65&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Mark, K.S., and T.P. Davis.  Stroke: Development, prevention and treatment with peptidase inhibitors.  Peptides 21(12):1965-1973, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/11150655?ordinalpos=64&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Bilsky, E.J., R.D. Egleton, J.D. Huber, H. Jones, H.I. Yamamura, J. Janders, T.P. Davis, P. Davis, F. Porreca, V.J. Hruby, S.A. Mitchell, M.M. Palian, R. Polt.  Enkephalin glycopeptide analogs produce analgesia with reduced dependence liability.  J. Med. Chem. 43(13):2586-2590, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/10891118?ordinalpos=68&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Witt, K.A., R.D. Egleton, C. Slate, V.J. Hruby, and T.P. Davis.  Assessment of stereoselectivity of trimethylphenylalanine analogs of δ-opioid [D-Pen2, D-Pen5]-enkephalin.  J. Neurochemistry 75(1):424-435, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/10854288?ordinalpos=69&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D., S.A. Mitchell, R. Polt, V.J. Hruby, J.D. Huber and T.P. Davis.  Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.  Brain Research 881(1):37-46, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/11033091?ordinalpos=66&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Newcomb, R., T. Abbruscato, T. Singh, L. Nadasdi, T. P. Davis and G. Miljanich.  Bioavailability of ziconotide in brain: Influx from blood, stability and diffusion.  Peptides 21:491-501, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/10822104?ordinalpos=70&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rounseville, M., and T.P. Davis.  Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.  J Molecular Endocrinology 25(1):121-128, 2000.
http://www.ncbi.nlm.nih.gov/pubmed/10915224?ordinalpos=67&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J. and T.P. Davis.  Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: Influence of astrocyte contact.  Brain Research 842(2):277-286, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/10526124?ordinalpos=73&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Gentry, C.L., R.D. Egleton, T. Gillespie and T.P. Davis.  The effect of halogenation on blood-brain barrier permeability of a novel peptide drug.  Peptides 20(10):1229-1238, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/10573295?ordinalpos=72&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rao, R.K., O. Koldovsky, C. Williams and T.P. Davis.  Milk inhibits somatostatin degradation in suckling rat jejunum in vivo.  J. Pediatric Gastroenterology and Nutrition, 28(1):84-94, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/9890475?ordinalpos=76&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D. and T.P. Davis.  Transport of the opioid receptor agonist [D-Pen2, D-Pen5]enkephalin across the blood-brain barrier involves transcytosis.  J. Pharm. Sci., 88(4):392-397, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/10187748?ordinalpos=75&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J. and T.P. Davis.  Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.  J. Pharmacol. Exp. Ther. 289(2):668-675, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/10215638?ordinalpos=74&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Kline, J.P., I. Bell, G.E. Schwartz, V. Hau and T.P. Davis.  Repressive and defensive coping styles predict resting plasma endorphin levels in the elderly.  Biological Psychology 49:295-302, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9858058?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D., Abbruscato, T.J., S. Williams, and T.P. Davis.  Transport of opioid peptides into the central nervous system.  J. Pharm. Sci. 87(11):1433-1439, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9811502?ordinalpos=78&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Gillespie, T, J. Erenberg, J.E. Taylor, S. Kim, J. Dong, V. Hau and T.P. Davis.  Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution.  J. Pharmacol. Exp. Ther. 285(1):95-104, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9535998?ordinalpos=82&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Li, G., W. Haq, L. Xiang, B.-S. Lou, R. Hughes, I.A. DeLeon, P. Davis, T.J. Gillespie, M. Romanowski, X. Zhu, A. Misicka, A.W. Lipkowski, F. Porreca, T.P. Davis, H.I. Yamamura, D.F. O’Brien and V.J. Hruby.  Modifications of the 4,4'-residues and SAR Studies of Biphalin, a highly potent opioid receptor active peptide.  Bioorganic & Medicinal Chemistry Letters 8(5):555-560, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9871617?ordinalpos=77&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Slaninova, J., Appleyard, S., A. Misicka, A.W. Lipkowski, T. Abbruscato, T.P. Davis, V.J. Hruby and H.I. Yamamura.  (125I-Tyr1) Biphalin binding to opioid receptors of rat brain and NG 108-15 cell membranes.  Life Sciences 62, 14: PL199-PL204, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9570343?ordinalpos=83&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Moody, T.W., Mayr, C.A., T. Gillespie and T.P. Davis.  Neurotensin is metabolized by endogenous proteases in prostate cancer cell lines.  Peptides 19(2):253-258, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/9493857?ordinalpos=84&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Egleton, R.D. and T.P. Davis.  Bioavailability and transport of peptides and peptide drugs into the brain.  Peptides 18(9):1431-1439, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/9392847?ordinalpos=91&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Bell, I.R., G.E. Schwartz, R.R. Bootzin, V. Hau and T.P. Davis.  Elevation of plasma beta-endorphin levels of shy elderly in response to novel laboratory experiences.  Behavioral Medicine 22(4):168-173, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/9138625?ordinalpos=92&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Waters, S.M., M.P. Rounseville and T.P. Davis.  Effect of dopaminergic drugs on processing and degradative neuropeptidase mRNA in rat frontal cortex and caudate-putamen.  Brain Research 754:28-34, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/9134956?ordinalpos=89&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Thomas, S.A., T.J. Abbruscato, V.S. Hau, V.J. Hruby and T.P. Davis.  Structure-activity relationships of a series of [D-ALA2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability1.  J. Pharmacol. Exp. Ther. 281(2):817-825, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9152390?ordinalpos=87&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J., S.A. Williams, V.J. Hruby and T.P. Davis.  Brain and spinal cord distribution of biphalin, correlation with opioid receptor density and mechanism of CNS entry.  J. Neurochemistry 69(3):1236-1245, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/9282948?ordinalpos=85&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Thomas, S.A., T.A. Abbruscato, V.J. Hruby, and T.P. Davis.  The entry of [D-Penicillamine2,5] enkephalin into the central nervous system: Saturation kinetics and specificity.  J. Pharmacol. Exp. Ther. 280(3):1235-1240, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/9067309?ordinalpos=90&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J., S.A. Williams, V.J. Hruby, and T.P. Davis.  Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: Comparison with morphine.  J. Pharmacol. Exp. Ther.  280(1):402-409, 1997.
http://www.ncbi.nlm.nih.gov/pubmed/8996221?ordinalpos=93&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Moreau, J.-P., S. Kim, J.Z. Dong, F. Ignatious, S. Jackson, S.C. Moreau, B.A. Morgan, F. Touraud, J.E. Taylor, B. Tissier, M. Pellet, W. Murphy, and T.P. Davis.  Improved analogs and novel delivery systems for somatostatin octapeptides.  Metabolism, Vol. 45, No. 8, Suppl. 1, pp 24-26, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8769374?ordinalpos=28&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konkoy, C.S. and T.P. Davis.  Ectoenzymes as sites of peptide regulation.  Trends in Pharmacological Sciences 17(8):288-294, 1996. (Review)
http://www.ncbi.nlm.nih.gov/pubmed/8810875?ordinalpos=94&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Waters, S., Konkoy, C.S. and T.P. Davis.  Haloperidol and Apomorphine differentially affect neuropeptidase activity.  J. Pharmacol. Exp. Ther. 277:113-120, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8613907?ordinalpos=97&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Greene, D.L., V.S. Hau, A. Misicka, R. Lipkowski, T. Abbruscato, T. Gillespie, V. J. Hruby and T.P. Davis.  Enkephalin analog pro-drugs: An assessment of in vitro  conversion, enzyme cleavage characterization and blood-brain barrier permeability.  J. Pharmacol. Exp. Ther. 277:1366-1375, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8667199?ordinalpos=96&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Abbruscato, T.J., S.A. Williams, V.J. Hruby and T.P. Davis.  Blood-to-CNS entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives.  J. Pharmacol. Exp. Ther. 276:1049-1057, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8786534?ordinalpos=99&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konkoy, C.S., S.M. Waters and T.P. Davis.  Subchronic haloperidol administration decreases aminopeptidase N activity and met-enkephalin metabolism in rat striatum and cortex.  European J. Pharmacol. 297:47-51, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8851165?ordinalpos=101&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Bell, I.R., G.E. Schwartz, R.R. Bootzin, V. Hau, and T.P. Davis.  Time-dependent sensitization of plasma beta-endorphin in community elderly with self-reported environmental chemical odor intolerance.  Biological Psychiatry 40:134-143, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8793045?ordinalpos=95&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum        

Williams, S., T.S. Abbruscato, V.J. Hruby, and T.P. Davis.  The passage of a delta opioid receptor selective enkephalin, DPDPE, across the blood-brain and blood CSF barriers.  J. Neurochemistry 66:1289-1299, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8769896?ordinalpos=100&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Mania-Farnell, B.L., I. Botros, R. Day, and T.P. Davis.  Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin producing cell lines.  Peptides 17:47-54, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8822509?ordinalpos=103&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Rao, R.K., M Shantaon, S. Levenson, A. Raja, T.P. Davis, and A. Rao.  Molecular variants of epidermal growth factor in malignant astrocytoma.  Peptides 17(1):179-181, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8822528?ordinalpos=102&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Hruby, V.J., N. Collins, F.-D. Lung, J.-P. Meyer, T.P. Davis, H.I. Yamamura and F. Porreca.  Design of peptides and peptidomimetics for delta and kappa opioid receptor subtypes.  Regulatory Peptides 54:123-124, 1995.

Hruby, V.J., T.P. Davis, R. Polt, F. Porreca, D. O’Brien, H.I. Yamamura, H. Bartosz, L. Szabo, T.J. Gillespie, A. Misicka, A. Lipkowski, X. Qian, G. Li, D. Patel and G. Bonner.  Design and synthesis of peptide ligands with unique biochemical and biological profiles at opioid receptors that cross the blood brain barrier.  Analgesia 1:469-472, 1995.

Mania-Farnell, B.L., I. Botros, and T.P. Davis.  Modulation of CCK mRNA in cell lines in response to isoproteranol and retinoic acid.  Neuropeptides 29:221-227, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8584140?ordinalpos=105&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Meyer, J.-P., T.J. Gillespie, V.J. Hruby, and T.P. Davis.  In vitro stability of some reduced peptide bond pseudopeptide analogs of dynorphin A. Peptides 16(7):1215-1219, 1995.   http://www.ncbi.nlm.nih.gov/pubmed/8545241?ordinalpos=112&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konkoy, C.S. and T.P. Davis.  Regional metabolism of met-enkephalin and CCK on intact rat brain slices:  Characterization of specific peptidases.  J. Neurochemistry. 65(1):2773-2782, 1995.   http://www.ncbi.nlm.nih.gov/pubmed/7595577?ordinalpos=104&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Waters, S.M., and T.P. Davis.  Alterations of substance P metabolism and neuropeptidases in Alzheimer's disease.  J. Gerontology 50A: B315-B319, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7545530?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Schetz, J.A., C. Mayr, J.-P. Moreau, J. Taylor, and T.P. Davis.  Distribution and pharmacokinetics of a potent peptide antagonist of parathyroid hormone and parathyroid hormone related protein in the rat.  J. Pharmacol. Exp. Ther. 274(3):1456-1462, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7562522?ordinalpos=106&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Waters, S.M., C. Konkoy and T.P. Davis.  Neuropeptide metabolism on intact, regional brain slices: Effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation.  J. Pharmacol. Exp. Ther. 274: 783-789, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7543572?ordinalpos=108&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Slaninova, J., R.J. Knapp, S.J. Weber, T.P. Davis, S.N. Fang, V.J. Hruby,  H.I. Yamamura.  [125I]SNF-8702: A selective radioligand for cholecystokinin B receptors.  Peptides 16(2):221-224, 1995.   http://www.ncbi.nlm.nih.gov/pubmed/7784252?ordinalpos=113&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hruby, V.J., A. Misicka, A.W. Lipkowski, R.C. Haaseth, H. Bartosz-Beechowski, X. Qian, N. Collins, J.P. Meyer, L. Szabo, R. Polt, F. Porreca, T.P. Davis and H.I. Yamamura.  New opioid compounds in analgesia.  Regulatory Peptides S71-S72, 1994.

Mania-Farnell, B.L., B.J. Merrill, H.I. Yamamura and T.P. Davis.  Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC.  Annals of the New York Academy of Sciences 713:446-449, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7514375?ordinalpos=119&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Haaseth, R.C., P.J. Horan, E.J. Bilsky, T.P. Davis, T. Zalewska, J. Slaninova, H.I. Yamamura, S. Weber, T.P. Davis, F. Porreca and V.J. Hruby. [L-Ala3] DPDPE: A new enkephalin analog with a unique opioid receptor activity profile.  Further evidence of delta opioid receptor multiplicity.  J. Medicinal Chemistry 37:1572-1577, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8201592?ordinalpos=117&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Brownson, E.A., T.J. Abbruscato, T.J. Gillespie and T.P. Davis.  Effect of peptidases at the blood brain barrier on the permeability of enkephalins.  J. Pharmacol. Exp. Ther. 270(2):675-680, 1994.                 http://www.ncbi.nlm.nih.gov/pubmed/7915319?ordinalpos=114&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konkoy, C.S., S.M. Waters and T.P. Davis. Acute administration of neuroleptics decreases neurotensin metabolism on intact regional rat brain slices.  J. Pharmacol. Exp. Ther. 269(2):555-563, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7910209?ordinalpos=118&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Polt, R., Porreca, F., Lajos Z.S., Bilsky, E.J., Davis, T.P., Davis, T.P., Horvath, R., McCormick, J.M., Yamamura, H., Hruby, V. Glycopeptide enkephalin analogues cross the blood-brain barrier in vivo to produce analgesia in mice.  Proc. Nat. Acad. Sci. USA 91:7114-7118, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8041755?ordinalpos=115&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Oakes, M.G., and T.P. Davis.  The ontogeny of enzymes involved in the post-translational processing and metabolism of neuropeptides.  Developmental Brain Research 80:127-136, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7955337?ordinalpos=116&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Quay T., Slaughter C., Davis T.P., Merrill B.J., Hersh L.B.  Positional effects in the neutral endopeptidase (enkephalinase) reaction.  Archives in Biochemistry and Biophysics 308(1):133-136, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8311445?ordinalpos=121&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rao, R.K., H.-H. Chang, S. Levenson, F. Porreca, P. Brannon, T.P. Davis, and O. Koldovsky.  Ontogenic differences in the inhibition of gastric acid secretion by epidermal growth factor.  J. Pharmacol. Exp. Therap. 266(2):647-654, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8355198?ordinalpos=128&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Mania-Farnell, B., P.N.M. Konings, B. Merrill, and T.P. Davis.  Differential regulation of  CCKmRNA in the human neuroblastoma cell line SK-N-MC-9c in response to second  messenger activators.  FEBS Letters 335(1):65-68, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7694875?ordinalpos=122&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Horan, P., A. Mattia, E.J. Bilsky, S. Weber, T.P. Davis, V.J. Hruby, and F. Porreca.  Antinociceptive profile of biphalin, a dimeric enkephalin analog.  J. Pharmacol. Exp. Ther. 265:1446-1454, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8389867?ordinalpos=130&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Clark, D.A., R. Day, N. Seidah, T.W. Moody, F. Cuttitta and T.P. Davis. Protease inhibitors suppress in vitro growth of human small cell lung cancer.  Peptides 14:1021-1028, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7506831?ordinalpos=127&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Horan, P.J., K.D. Wild, A. Misicka, A. Lipkowski, V.J. Hruby, S.J. Weber, T.P. Davis, H.I. Yamamura and F. Porreca.  Agonist and Antagonist Profiles of (D-Ala2, Glu4) Deltorphin and its (Cys4) - and (Ser4) Derivatives:  Further evidence of opioid delta receptor multiplicity.  J. Pharmacol. Exp. Ther. 265:896-902, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8388462?ordinalpos=131&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Weber, S.J., T.J. Abbruscato, V.J. Hruby, H.I. Yamamura and T.P. Davis.  Assessment of an in vitro Blood-Brain Barrier model using several [met]5 enkephalin opioid analogs.  J. Pharmacol. Exp. Ther. 266:1649-1655, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8371162?ordinalpos=125&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konings, P.N.M., Farnell, B., M.C. Beinfeld, B.J. Merrill, T.W. Moody, R. Day, N.G. Seidah, and T.P. Davis.  Processing, release and metabolism of cholecystokinin in SK-N-MC1XC cells. Neuropeptides 25:19-30, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8413849?ordinalpos=129&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konkoy, C., M.J. Oakes, and T.P. Davis. Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions. Peptides 14:1017-1020, 1993.       http://www.ncbi.nlm.nih.gov/pubmed/7904340?ordinalpos=126&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Horan, P., W. Kazmierski, R. Ferguson, V.J. Hruby, S. Weber, T.P. Davis, L. Fang, R. Knapp, H.I. Yamamura, T. Kramer, T.F. Burks and F. Porreca.  Unexpected antinociceptive potency of cyclic [D-Tca1]-CTAP:  Potential for a novel mechanism of action. Eur. J. Pharmacol. 233:53-62,1993. http://www.ncbi.nlm.nih.gov/pubmed/8386089?ordinalpos=132&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rao, R.K., O. Koldovsky and T.P. Davis.  Fate of intraduodenally administered somatostatin in rats in vivoPeptides 14(6):1199-1203, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7907789?ordinalpos=47&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Fang L., Knapp R.J., Matsunaga T., Weber S., T.P. Davis, Hruby V., Yamamura H.I. Synthesis of [4'-125I-Phe3,Glu4]deltorphin and characterization of its delta opioid receptor binding properties.  Life Sciences 51:189-193, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1331636?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Banks, W.A., K.L. Audus and T.P. Davis.  Permeability of the Blood-Brain Barrier to Peptides: An Approach to the Development of Therapeutically Useful Analogs.  Peptides 13:1289-1294, 1992.   http://www.ncbi.nlm.nih.gov/pubmed/1494505?ordinalpos=135&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Gillespie, T.J., P.N.M. Konings, B. Merrill and T.P. Davis.  A specific enzyme assay for aminopeptidase M. in rat brain.  Life Sciences 51(26):2097-2106, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1361957?ordinalpos=138&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Weber, S.J., D.L. Greene, V.J. Hruby, H.I. Yamamura, F. Porreca and T.P. Davis. Whole body and brain distribution of [3H] DPDPE after I.P., I.V., P.O., and S.C. administration.  J. Pharmacol. Exp. Ther. 263(3):1308-1316, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1469637?ordinalpos=134&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., S. Crowell, J. Taylor, J.P. Moreau, D. Coy, J. Staley and T.W. Moody.  Metabolic Stability and tumor inhibition of Bombesin/GRP receptor antagonists.  Peptides 13:401-407, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1329046?ordinalpos=136&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Weber, S., L. Trombley, P. Davis and T.P. Davis.  Metabolic half-life of somatostatin and peptidase activities are altered in Alzheimer's disease.  J. Gerontology 47(1):B18-B25, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1346149?ordinalpos=139&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., T.J. Gillespie and P.N.M. Konings.  Specificity of neurotensin metabolism by regional rat brain slices.  J. Neurochemistry 58:608-617, 1992.http://www.ncbi.nlm.nih.gov/pubmed/1729405?ordinalpos=137&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Weber, S.J., S. Sharma, G. Toth, L. Hersh, V. Hruby, D. Greene, H.I. Yamamura and T.P. Davis.  Distribution and analgesia of [D-Pen2,D-Pen5] enkephalin and two halogenated analogues following intravenous administration.  J. Pharmacol. Exp. Ther. 259(3):1109-1117, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1762065?ordinalpos=140&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rao, R.K., O. Koldovsky and T.P. Davis.  Regional differences in the gastrointestinal processing of epidermal growth factor in suckling rats.  American J. Physiol. 261:G790-G798, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1951698?ordinalpos=141&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Knapp, R.J., S. Sharma, G. Toth, M. Duong, C. Bogert, T.P. Davis, V. Hruby and H.I. Yamamura.  [D-Pen2,4 I-Phe4,D-Pen5]enkephalin:  A  selective and high affinity radioligand for delta opioid receptors with exceptional specific activity.  J. Pharmacol. Exp. Ther. 258(3):1077-1083, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1653834?ordinalpos=142&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., T. Gillespie, J. Shook, K. Hawkins, P. Davis, H.I. Yamamura and T.F. Burks.  Changes in opioid receptor selectivity following processing of peptide E:  Effect on gut motility.  Gastroenterology 100:1603-1615, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1850373?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., S. Crowell, B. McInturff, R. Louis and T. Gillespie.  Neurotensin may function as a regulatory peptide in small cell lung cancer.  Peptides 12:17-23, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1646999?ordinalpos=144&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Konings, P., A.J. Culling-Berglund and T.P. Davis.  Chronic haloperidol and chlorpromazine treatment alters in vitro β-endorphin metabolism in rat brain.  Eur. J. Pharmacol. 191:115-128, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2086234?ordinalpos=146&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., G. Hoyer, P. Davis and T.F. Burks. Proenkephalin A derived peptide E and its fragments alter opioid contractility in the small intestine. Eur. J. Pharmacol. 191:253-261, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2086244?ordinalpos=145&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., B. McInturff, T.W. Moody and S.L. Crowell.  Protease inhibitors suppress in vitro clonal growth of human small cell lung cancer.  Eur. J. Pharmacol. 183(2):194-195, 1990. http://www.ncbi.nlm.nih.gov/pubmed/7506831

Morrill, M., R. Louis and T.P. Davis.  Haloperidol, chlorpromazine and apomorphine alter central regional neuropeptidase activity.  Eur. J. Pharmacol. 183(6):2318-2319, 1990.

Li, Z.W., K. Brendel, J. Van Nispen and T.P. Davis.  Neuropeptide processing in regional brain slices:  Effect of conformation and sequence.  J. Pharmacol. Exp. Ther. 253(2):851-857, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2140132?ordinalpos=149&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Newcomb, S.A., A.J. Culling-Berglund and T.P. Davis.  Endogenous levels of carotenoids in human buccal mucosa cells by RP-HPLC.  J. Chromatography 526(1):47-58, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2341545?ordinalpos=150&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Rao, R.K., O. Koldovsky and T.P. Davis.  Inhibition of intestinal degradation of somatostatin by rat milk.  American J. Physiology. 258:G426-G431, 1990. http://www.ncbi.nlm.nih.gov/pubmed/1969233?ordinalpos=151&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Rao, R.K., O. Koldovsky, P.F. Pollack, M. Korc, S. Wright and T.P. Davis.  Processing and transfer of epidermal growth factor in developing rat jejunum and ileum.  Peptides 11(6):1093-1102, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2087434?ordinalpos=147&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Crowell, S.L., H.S. Burgess and T.P. Davis.  Effect of mycoplasma on the autocrine stimulation of human small cell lung cancer in vitro by bombesin and β-endorphin.  Life Sciences 45:2471-2476, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2558267?ordinalpos=156&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., T.J. Gillespie and F. Porreca.  Peptide fragments derived from the β-chain of hemoglobin (hermorphins) are centrally active in vivoPeptides 10:747-751, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2587417?ordinalpos=154&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Staley, J., G. Fiskum, T.P. Davis, and T.W. Moody.  Neurotensin elevates cytosolic calcium in small cell lung cancer cells.  Peptides 10:1217-1221, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2560176?ordinalpos=152&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Davis, T.P., T.W. Moody, R. Liu, S. Crowell and H. Burgess.  β-endorphin and neurotensin stimulate in vitro clonal growth of human SCLC cells.  Eur. J. Pharmacol. 161:283-285, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2542049?ordinalpos=155&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Plezia, P.M., D.S. Alberts, Y.M. Peng, M.J. Xu, S. Sayers, T.P. Davis, E.A. Surwit and F.L. Meyskens.  The role of serum and tissue pharmacology studies in the design and interpretation of chemoprevention studies.  Preventive Medicine 18:680-687, 1989 http://www.ncbi.nlm.nih.gov/pubmed/2694162?ordinalpos=153&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum       

Culling-Berglund, A.J., S.A. Newcomb, M. Gagne, W.S. Morfitt and T.P. Davis.  A sensitive and specific procedure for the analysis of β-carotene in human skin.  J. Micronutrient Analysis 5:139-148, 1989.

Carrier, M., D.H. Russell, T.P. Davis, R.W. Emery and J.G. Copeland.  Value of urinary polyamines as noninvasive markers of cardiac allograft rejection in the dog.  Ann. Thorac. Surg. 45:158-163, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3277553?ordinalpos=160&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Margolis, S.A., and T.P. Davis.  Stabilization of ascorbic acid in human plasma, and its liquid-chromatographic measurement.  Clinical Chemistry 34:2217-2223, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3180412?ordinalpos=157&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Carrier, M., D.H. Russell, T.P. Davis, R.W. Emery and J.G. Copeland.  Urinary polyamines as markers of cardiac allograft rejection.  J. Thoracic Cardiovasc. Surgery 96(5):806-810, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3054342?ordinalpos=158&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Belyea, R.L., F.A. Martz, M. Madhisetty and T.P. Davis.  Intake, digestibility and energy utilization of corrugated paper diets.  Animal Feed Sci. and Tech. 17:57-64, 1987. http://www.sciencedirect.com/science/article/pii/0377840187900526

Carrier, M., J.G. Copeland, D.H. Russell, M.J. Perrotta, T.P. Davis and R.W. Emery.  Urinary polyamines are non-invasive markers of cardiac allograft rejection.  J. Heart Transplantation 6:286-289, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3316553?ordinalpos=162&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Conrad, K.A., T.C. Fagan, P. May Shar, T.P. Davis and D.G. Johnson.  Anti-hypertensive effects of parenteral nicardipine alone and with captopril. Clin. Pharm. and Therap. 42(1):113-118, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3297467?ordinalpos=164&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P. and A.J. Culling-Berglund.  Neuroleptic drug treatment alters in vitro central neurotensin metabolism. Psychoneuroendocrinology 12(4):253-260, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3659226?ordinalpos=166&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., A.J. Culling-Berglund, T.J. Gillespie and T.L. Smith. Ethanol treatment alters β-endorphin metabolism by purified synaptosomal membranes.  Peptides 8:467-472, 1987. http://www.ncbi.nlm.nih.gov/pubmed/2958786?ordinalpos=165&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., A.J. Culling-Berglund and H. Schoemaker.  Specific regional differences of β-endorphin metabolism in schizophrenics.  Life Sciences 39(26):2601-2609, 1986. http://www.ncbi.nlm.nih.gov/pubmed/2948088?ordinalpos=168&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., T.J. Gillespie, R. Yekta, and T.M. Hansen. Chromatographic characterization of nutritional components in a low calorie, juice based beverage.  Flussiges Obst. 11:577-580, 1986.

Davis, T.P., A. Han, and M.K. Yousef.  Central metabolism of β-endorphin in different species of temperature acclimated rodents.  Comp. Biochem. Physiol. 84c(1):105-111, 1986. http://www.ncbi.nlm.nih.gov/pubmed/2873940?ordinalpos=169&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Hameroff, S.R., R.C. Cork, J.L. Weiss, B.R. Crago, and T.P. Davis.  Doxepin effects on chronic pain and depression:  A controlled study.  Clin. J. of Pain 1:171-176, 1985. http://www.ncbi.nlm.nih.gov/pubmed/6321454?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Dray, A., and T.P. Davis.  The Proenkephalin A fragment metorphamide shows supraspinal and spinal opioid activity in vivoPeptides 6:217-221,1985. http://www.ncbi.nlm.nih.gov/pubmed/3839922?ordinalpos=173&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P. and A.J. Culling-Berglund.  High performance liquid chromatographic analysis of in vitro central neuropeptide processing.  J. Chromatography 327:279-292, 1985. http://www.ncbi.nlm.nih.gov/pubmed/2411750?ordinalpos=170&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Davis, T.P., Porreca, F., T.F. Burks, and A. Dray.  The Proenkephalin A fragment peptide E:  Central processing and in vivo CNS activity.  European J. Pharmacology 111:177-184, 1985. http://www.ncbi.nlm.nih.gov/pubmed/2990950?ordinalpos=171&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Peng, Y.-M., D.S. Alberts, and T.P. DavisIn vivo and in vitro metabolism of the new anticancer drug bisantrene.  Cancer Chemotherapy and Pharmacology 14:15-20, 1985. http://www.ncbi.nlm.nih.gov/pubmed/3965156?ordinalpos=174&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Alberts, D.S., Y.M. Peng, S. Leigh, T.P. Davis, and D.L. Woodward.  Disposition of Mitoxantrane in cancer patients.  Cancer Research 46:1879-1884, 1985.                               http://www.ncbi.nlm.nih.gov/pubmed/3978648?ordinalpos=172&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum