Blood Brain Barrier Alterations Induced By Pain and Stroke - Challenge to drug delivery
Chronic Pain and stroke affects over 100 million people a year in the U.S. and costs billions of dollars in medical treatment and lost productivity. To date many of the investigations concerning the blood brain barrier (BBB) and the delivery of therapeutics to the CNS have been performed in naive animals. It is becoming increasingly clear that the BBB is not a static barrier but can be modulated by a number of factors from the immune, neuronal , glial , endothelial and hormonal systems (Neurovascular Unit/NVU). During acute and chronic pain and stroke all of these NVU systems are activated. We are currently investigating the NVU , BBB tight junction protein structure and drug delivery transporter alterations induced by pain and stroke to determine how they affect the delivery of drugs to treat pain and stroke pathologies.